Yes have been on letrozole for three months: at the two month mark it all started. I have ankle and knee pain (my ankles are like hinges that don’t work in the morning - I have to ‘get them going’ with a hot pack), hot flushes in the afternoons, feeling down for no apparent reason, my nails are peeling off, my hair is starting to fall out at the front, some insomnia, snappiness. I’ve had to take a week off for a pause from dealing with all this. What a dreadful medication! To be honest, I hate it soooo much. It’s the worst part of treatment so far for sure. While I’m not likely to stop it, I can understand why people do. Surgeon said the other day; give it six months and some of this might settle, or we can change meds etc. Fortunately, I am doing quite a bit of exercise; it’s the only thing holding me together atm, so I do recommend that.