Remember too that if all women googled the potential side effects of pregnancy and childbirth, the human race would probably die out. Let's begin with A. Acne, bloating,candidiasis (thrush), diarrhoea, eclampsia. foetal death...and so on all through the alphabet. Most women get few if any. I've been on letrozole for four years now, and have other medical issues which affect all the connective tissues in my body. So, muscles, tendons, joints, blood vessels, internal organs...the lot. I can honestly say that although there has been an increase in joint and tendon issues, my feeling is that they would have deteriorated this much over the last four years in any event...letrozole or not. Other than that... my "lady garden" has dried up from formerly being a bounteous oasis, to now being sadly, the Gobi desert.