Glad to find this thread. On Letrozole 8 mths. Feel like I dont want to continue. Depression not natural for me. Wonder if thoughts of divorce just a side effect - have had a slightly challenging husband for 25 yrs ( he missed the silver anniversary of course -relationship for 35 yrs) . As well as memory, ( forgetting to make half the elements of a dinner) aches etc I am fighting with determined tennis exercise but tired after a short walk. Questioning why I am doing this. Although I take meds for thyroid & glaucoma am not a pill taker so extensive side effects really putting me off. Sorry, bit of a rant. Am seeing psychologist as teary all time but feel like will never feel better till off the AIs