Abemaciclib Verezenio side effects
Hi Ladies, I have recently started on Letrizole/Hormone Therapy, and Verenio / Abemaciclib and am struggling with the side effects. I am in the fortunate position in that both these drugs are bein...
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Hellooo!!
thank you! Spoke to ONC last night and he agreed that my dose needed to drop. My platelets have dropped again so he was going to reduce the dose in any case.
Will do another round of bloods in a month to see how the platelets are responding to the lower dose. There is no way I could have done another year on that higher dose. My ONC told me that almost no one can withstand the full dose and almost everyone has a reduction. I have a friend who is doing the full dose but the amount of horror stories she has told me about not getting to a toilet in time is pretty awful.
I will just need to be patient with my hair. It could always be worse!!
My oncologist told me that research shows a reduction of dose does not seem to affect the outcomes, and it was more beneficial to keep me on the medication at a lower dose than to stop it all together. If I can tolerate it that way, it's still beneficial, rather than have to give up because the higher dose is not suitable for me. 150x2 per day was absolutely not achievable long term for me, I had to stop after 5 weeks, it was awful. I had a 4 week break and started again.
As this is an added preventative treatment for me they said they want me to have a good quality of life as well.
The trial research is showing that people who were offered a reduction of dose early on were much more likely to finish the 2 years. People who were not offered a reduction were more likely to stop treatment, which I would have done as my body just couldn't tolerate it.
Sounds like our doctors are reading from the same literature, which is comforting. I'm in a similar boat to you - high risk of recurrence so this is preventative and I would like to give myself the best chance possible. If I can have a dose that doesn't impact my quality of life, then it is a win win in my book!