Hi, everyone. I am also at high risk (hormone receptive, Stage 3A 7 cm tumour and three lymph nodes involved) for mets and started taking Verzenio last month as well as Anastrazole. My oncologist was initally reluctant to reduce the dose and I struggled with diarrhoea and horrible stomach pains for ten days on 150mg twice a day. I kept a food and symptom diary for ten days and used this evidence to tell my oncologist how many times a day I went to the bathroom and how bad it was. My records convinced her to reduce the dose to 100 mg twice a day. I cannot believe the difference the lower dose made to my life! You will still have a good chance of reducing the risk on a lower dose (according to my oncologist). I felt like I had to spell out the side effects in a very clinical manner, though, because my oncologist needed to report these records to change the dose. I am glad it worked out for you @Jenni22. I also found a list of foods with low and high fibre and used a fibre supplement to bulk up my poo. I visited a Dietitian as well, which has helped with the nausea and low appetite.