Thanks @Cath62 and @Skande for sharing your experience with Abemaciclib and Ribociclib. Sorry to hear you have Mets Cath, its a timely reminder to be grateful I have the option of this treatment to reduce the risk of a recurrence. I’ve had a break of a month on the Abemaciclib and have been on a reduced dosage 100mg twice daily for 3 weeks now, pleased to say I’m feeling so much better. The diarrhoea is now a rare occurrence and I have a lot more energy. For me the fatigue was probably the biggest issue, so relieved this has improved. Good to hear some of the other issues improve after 12 months aswell. My red and white blood counts are low but not a major issue to date.