@Mellyb , like the other girls here I wouldn't be taking anything on board until you've had scans to confirm Xeloda isn't working. I would definitely get in touch with your regular oncologists office and ask that they contact them urgently. Did the Locum suggest stopping the Xeloda because again until you saw or heard from your regular oncologist I would be hesitant to do so ( unless other levels in your blood work aren't stable ) I have just been dignosed with stage 4, my cancer is currently contained to my aux lymph node,a spot at the base of my neck C7and was in a couple of nodes across my chest these have since shrunk or disappeared. I started Xeloda almost 6 weeks ago and am about to start my 3rd cycle, all is going well so far thankfully. My oncologist is rescanning me after the 4th cycle and if Xeloda isn't doing what it should she said there are many other options available. I realise our treatments are different and you are further down the treatment line to me but there is always something. I have a girlfriend 2 years on from her stage 4 diagnosis, her spine was full of mets as was her liver she is now in remission. Her treatment is still 3 weekly and she has been through the wringer but she is really well and stable currently. I know how being told there is nothing they can do would be horrifying but without those scans no one can say that with any degree of certainty. Get on that ph @Mellyb and get them getting you some decent follow up and care!