I was on Herceptin and Perjeta for 6 years, I am on a break. they finally changed the rules allowing a break and my doctor had talked of stopping it after 5 years, I managaed to drag it out to 100 doses which ended up being the 6 years due to a few delayed or missed doses over the years. I have had 2 scans that have been ok and I am due for a PET scan in February so fingers crossed. My secondaries were in the 3 different lymph nodes so after Chemo, raditaion and the time on Herceptin he felt it was worth having a break. It is a worry none the less but at least I do have the option to go back on it. I didn't have too may side affects