Hi @wokeupthismorning, in with you about the skin my hands are dreadfully dry all the time and the skin peels off, yes hair is getting thinner especially right at the front, I’ve been on same combination as you since April, 2019, only difference is I’m on 600mg of kisqali. I try not to think about the Mets much, yes can be lonely sometimes especially when people don’t understand exactly what your going through, my last blood test the ca 15 had jumped from 62 to 82 so another blood test in a couple weeks time hopefully hasn’t kept going up, stressful time