Hi @angelo I'm not where you are but agree with what the others say. If work is getting you down then think about how you might scale down or retire. If you cannot see yourself happy not working - then stick with it. Are you able to negotiate a break or possibly a sideways move (mentoring?) with less hours? I don't know what your onc is measuring your prognosis on, but from what I've heard, it's length of string stuff. What's really important is that you enjoy what time you have as much as possible, whether it's measured in months or decades.