Hi @CRM,
Just saw your question. I'm on Zoladex and Letrozole at the same time. Zoladex for 12 months, then a review. I'm half-way there. The Letrozole is for a minimum of five years, if I can tolerate it. It's difficult to say which side effects are due to either or both... my feeling at the moment is that Zoladex makes the joint and tendon pain worse, as it wanes just before I have to have the next injection, then worsens the week after. As with all of these things, I guess one has to perservere if possible. I'm hoping my body will adjust at some point. Six months of Tamoxifen on its own caused endometrial hyperplasia, which is why I'm now on the other stuff. I'm 55 but had not gone through menopause. My tumour was very hormone receptive, hence the need to shut down my ovaries. It sounds like you are younger. I hope you are feeling OK on the Zoladex/Tamoxifen combo. I'm no expert, but I believe the Zoladex will prevent endometrial hyperplasia. If you feel OK, stick with it. As may see from my and others various states of mind when checking in here at BCNA, it's a bit of a rollercoaster. I've had a hysteroscopy with biopsy and currettage of the uterus this week, then a bilateral mammogram/ultrasound. The waiting as a pubic patient was the worst part. The actual event (day surgery under general anaesthetic) was OK. Just waiting for the results now. All the best CRM. Lx
