Hi @cassidie, I am just over 3 wks into tamoxifen. So far for me a couple of rough nights sleep, hot flushes but not as bad as I expected. My oncologist has given me tamoxifen instead of AIs because of some osteoarthritis I have as she indicated tamoxifen doesn't cause joint pain as badly as the AIs do. Go figure! Who knows, I think all these drugs impact us all differently. No surprise really as our cancers are all unique and we react to chemo, radium and hormone suppression drugs differently. Ho I e everything improves for you.