Hi @Willow26 I have been taking Letrozole since August 2017. I have had joint pain hips , knees and ankles but I was also osteoporotic before treatment and had had a fracture.I find two things helpful a bi- weekly Stretch and Balance class and walking for an hour per day. The walking seems to enable me to walk thru discomfort after 15 or so minutes - I am far from athletic but have learnt how important this is to my health from having break from it for a variety of reasons over Christmas.I Also was advised by the medical oncologist at the outset when I expressed concern about joint pain to take Krill oil tablets which I do daily. Hope this helps there are a multitude of side effects with our treatment but they do not effect all of us in the same way or indeed as Afraser has indicated she has had no problems at all. For me it is the best protection I have against recurrence and that is why I will stay on it. Happy to answer any questions I can.