Good idea @Locksley One of the things I have noticed as I've gone on with Letrozole is that it is really easy to injure myself, often doing nothing in particular. I have had a twinge in my knee just from walking upstairs and then found it's gotten worse and caused significant pain for weeks before healing. So, it is possible that you have just injured your wrist and it's going to take some time to repair. Crap, I know, but that's the sort of thing that oestrogen protects us from. As my onc says, people don't realise that a tiny little pill can have such a major effect on the body. Anyway, have the painkillers and get it checked out - all the best.