Hi @SuzyS, I have been on letrozole since Dec 2021, I have metastatic breast cancer so there is no end date for letrozole for me unless side effects get to much. I have bone ache in most of the joint areas, this only started in the last 3 months, hot flushes were give when I first started but they have calmed down now and I don't get them as bad. Had bone density scan recently and still all good. Am also on another drug for metastatic so working out which one is causing which side effect is not easy. I have thinning hair as well but have just cut my hair to a short style. Loved my long hair before cancer but you learn to adapt and accept. I embrace the hair I have and have fun with it. Good luck with your treatment xxx oh yeah Debono have the dryness and pain when sex, have not yet found a solution for that except we don't have sex, not so bad for me as I have no libido, not so good for the husband🙄😜