I've been on Letrozole since mid 2017...so 7 years now. I have other medical conditions Autoimmune), which include systemic scleroderma, dermatomyositis, Sjogrens syndrome as well as antiphospholipid antigen syndrome. All are mixed connective conditions which affect the collagen in my body and it affects my kidneys, lungs, heart, skin, joints, tendons, muscles, ligaments and blood vessels. As a result, current issues in these areas of my body are hard to tell which is from what. My rheumatologist has told me that my problems are well in line of what he would expect with these conditions after seven years and that they would exist, letrozole or not. Aside from that, the only symptoms I can attribute to the letrozole is some hair thinning and some vaginal dryness...both of which are acceptable if it continues to keep the Cancer Clowns away.