Hi - so good to read of similar experiences. I've been on Herceptin and Arimidex for six years. Very tender feet for four years and this last year severe spasms in rib area. I found a physio I trust just a a few weeks ago, basically I have tensed muscles in an attempt to compensate for the foot pain. Chassis has been under acute stress for years. In the last six months the joint pain and stiffness has increased and some days are really bad - I take Voltarin and/or Panadol. The acute pain in turn releases adrenalin which has the effect of a toxic cocktail - bit of a round robin. Social life is very limited at the moment. The physio has given me gentle exercises to stretch and strengthen the tight and neglected muscles and I like knowing that I can do something, however, this does not prevent the side effects of the drugs. The other night my left knee played up, intense pain and I used a surgical stocking for the day. I use a walker some days as it eases my feet and keeps the 'chassis' in alignment and I'm more likely to use the correct muscles to walk. I'm 70 and was the fit and flexible sister - adjusting to a new self image. Good to share. Beryl xxxxxx