Hi there @Annetted...sorry to hear of the latest development for you. I have been on blood thinners, heparin, clexane and mostly warfarin for over twenty years now. Long before the breast cancer, diagnosed in 2016, I have had pulmonary embolisms as well as dvt's. Two in my right arm at different times, the result now being on very high levels. My INR target is 3.5 - 4, which is very high. Without the warfarin, at such high levels, I run the risk of another embolism, possible fatal, and with my blood so "runny", the risk of a major bleed, also potentially fatal. I am on letrozole, and have been for almost 18 months now. My large multidisciplinary medical team explain the different options with their associated risks, and then we make the decisions. Once this clot has dissolved, you may perhaps need to remain on thinners, but ask about restarting the AI therapy, perhaps with letrozole or similar, depending on if you have passed menopause or not. Best of luck and sending a big (((hug))).