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I had hormone receptive BC, chemo, double mastectomy and oopherectomy (also BRACA2 ). I've been having a lot of side effects which I put down to Anastroz...","body@stringLength":"531","rawBody":"hi, live been on Anastrozole since May 2017. I had hormone receptive BC, chemo, double mastectomy and oopherectomy (also BRACA2 ). I've been having a lot of side effects which I put down to Anastrozole: confusion, weight gain, lethargy, fractured ankle,joint pain and stiffness, as well as bouts of depression. I'm considering speaking to my oncologist about changing to Tamoxifen. I'm just wondering if anyone has had similar issues on Anastrozole and if you changed to Tamoxifen? Any advice would be appreciated. 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I had hormone receptive BC, chemo, double mastectomy and oopherectomy (also BRACA2 ). I've been having a lot of side effects which I put down to Anastrozole: confusion, weight gain, lethargy, fractured ankle,joint pain and stiffness, as well as bouts of depression. I'm considering speaking to my oncologist about changing to Tamoxifen. I'm just wondering if anyone has had similar issues on Anastrozole and if you changed to Tamoxifen? Any advice would be appreciated. "},"Conversation:conversation:36695":{"__typename":"Conversation","id":"conversation:36695","solved":false,"topic":{"__ref":"ForumTopicMessage:message:36695"},"lastPostingActivityTime":"2018-04-16T07:49:59.000-07:00","lastPostTime":"2018-04-16T07:49:59.000-07:00","unreadReplyCount":72,"isSubscribed":false},"ModerationData:moderation_data:36695":{"__typename":"ModerationData","id":"moderation_data:36695","status":"APPROVED","rejectReason":null,"isReportedAbuse":false,"rejectUser":null,"rejectTime":null,"rejectActorType":null},"Revision:revision:36695_1":{"__typename":"Revision","id":"revision:36695_1","lastEditTime":"2018-01-31T18:25:09.000-08:00"},"ForumReplyMessage:message:36709":{"__typename":"ForumReplyMessage","id":"message:36709","conversation":{"__ref":"Conversation:conversation:36695"},"author":{"__ref":"User:user:16650"},"revisionNum":1,"uid":36709,"depth":1,"hasGivenKudo":false,"subscribed":false,"board":{"__ref":"Forum:board:hormone-blocking-therapy"},"subject":"Re: Anastrozole","readOnly":false,"editFrozen":false,"moderationData":{"__ref":"ModerationData:moderation_data:36709"},"parent":{"__ref":"ForumTopicMessage:message:36695"},"body":"Oh dear, fret not!! I was only standing up for the aged as I rapidly head in that direction! Too true, we all end up having to become our own \"experts\" in spite of the lack of qualifications. We do want the real experts to say, definitively, this is good and this is bad. Problem is most treatments are not that precise, or not for everyone. Sometimes not predictable. Sometimes weird! For what it's worth and with the notable exception of this site, I gave up most other sites and all blogs years ago. People who are scared, unhappy and possibly aggrieved are likely to participate, looking for help, sympathy. People who are doing fine mainly don't. So at very least, you can get a skewed impression. Would you take the advice of a patient over a highly regarded neurosurgeon if you are having brain surgery? Medicos don't get it all right, they are human. I may have been lucky but mine respond well to rational questions and don't mind lots of them. They are also able to say if they don't know. My oncologist warned of bone density impact, has been monitoring it and has already said my next test will be a major factor in whether he recommends another five years or stopping. I know he is good on latest research but doesn't act till he sees it replicated. Not a fad surfer! But yes, it's my choice. I have no idea why I sailed through (mostly!) chemo and others are sick and fatigued. I have never heard a rational argument put forward. No, attitude isn't everything. Like getting cancer in the first place, at least some of it is just bad luck. Perhaps that's the hard one for some - you didn't do anything (wrong or unwise), providence is not chastising you, it just happened. My belief system, such as it is, lies mainly in the glorious chaos of a potentially random universe, so it doesn't bug me as much as others!! Take care and take some time out from worry if you can. None of us actually knows how long we have in this life, so it makes sense to enjoy what we have for as long as we can. Best wishes.","body@stringLength":"2016","rawBody":"Oh dear, fret not!! I was only standing up for the aged as I rapidly head in that direction! Too true, we all end up having to become our own \"experts\" in spite of the lack of qualifications. We do want the real experts to say, definitively, this is good and this is bad. Problem is most treatments are not that precise, or not for everyone. Sometimes not predictable. Sometimes weird! For what it's worth and with the notable exception of this site, I gave up most other sites and all blogs years ago. People who are scared, unhappy and possibly aggrieved are likely to participate, looking for help, sympathy. People who are doing fine mainly don't. So at very least, you can get a skewed impression. Would you take the advice of a patient over a highly regarded neurosurgeon if you are having brain surgery? Medicos don't get it all right, they are human. I may have been lucky but mine respond well to rational questions and don't mind lots of them. They are also able to say if they don't know. My oncologist warned of bone density impact, has been monitoring it and has already said my next test will be a major factor in whether he recommends another five years or stopping. I know he is good on latest research but doesn't act till he sees it replicated. Not a fad surfer! But yes, it's my choice. I have no idea why I sailed through (mostly!) chemo and others are sick and fatigued. I have never heard a rational argument put forward. No, attitude isn't everything. Like getting cancer in the first place, at least some of it is just bad luck. Perhaps that's the hard one for some - you didn't do anything (wrong or unwise), providence is not chastising you, it just happened. My belief system, such as it is, lies mainly in the glorious chaos of a potentially random universe, so it doesn't bug me as much as others!! Take care and take some time out from worry if you can. None of us actually knows how long we have in this life, so it makes sense to enjoy what we have for as long as we can. Best wishes.","kudosSumWeight":2,"repliesCount":0,"postTime":"2018-02-03T18:06:04.000-08:00","images":{"__typename":"AssociatedImageConnection","edges":[],"totalCount":0,"pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null}},"attachments":{"__typename":"AttachmentConnection","pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null},"edges":[]},"timeToRead":2,"currentRevision":{"__ref":"Revision:revision:36709_1"},"latestVersion":null,"metrics":{"__typename":"MessageMetrics","views":0},"visibilityScope":"PUBLIC","isEscalated":null,"placeholder":false,"originalMessageForPlaceholder":null,"messagePolicies":{"__typename":"MessagePolicies","canModerateSpamMessage":{"__typename":"PolicyResult","failureReason":{"__typename":"FailureReason","message":"error.lithium.policies.feature.moderation_spam.action.moderate_entity.allowed.accessDenied","key":"error.lithium.policies.feature.moderation_spam.action.moderate_entity.allowed.accessDenied","args":[]}}},"customFields":[],"replies":{"__typename":"MessageConnection","edges":[],"pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null}}},"CachedAsset:theme:customTheme1-1743643614981":{"__typename":"CachedAsset","id":"theme:customTheme1-1743643614981","value":{"id":"customTheme1","animation":{"fast":"150ms","normal":"250ms","slow":"500ms","slowest":"750ms","function":"cubic-bezier(0.07, 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