As a casual observation over the past few months I am wondering whether women who have experienced chemotherapy are finding hormone therapy more debilitating than those who have not as chemo may impact on joints. I am on an AI - Letrozole - did not have chemo . I take 2 Caltrate Bone and Muscle Health daily ,have a 6monthly Prolia injection and have managed ok thus far with joint pain . Only side effect I find is a tendency to the blues/ depression.I found a daily 1 hour walk helpful but am struggling to keep it up because of hot weather and busy family of teenagers on holidays interrupting my routine.The walk seems to enable me to walk thru joint pain , reduce fluid retention and maybe it elevates my mood by releasing endorphins. I might add I had radiotherapy and have a bit of problems with my ribs I think as a result. Also eating healthily esp low sugar/ fat seems to help with the blues but Christmastime is difficult for me as all my favourite foods appear.One thing I am aware of is that my cholesterol which is normally low more than doubled since being on Letrozole and gather is a common side effect.