Hi @Ellenwatson65, I,m so sorry you've had such a bad time after your first chemo. I was diagnosed in 2016 with Stage 3, Grade 3, Triple Positive, multifocal, (more than one lump), and with node involvement. So...an aggressive cancer, just short of stage 4. I had 4 X AC chemo, followed by 12 X Paclitaxel and Herceptin for just under a year. I had chemo first, followed by a bilateral mastectomy with node clearance on the left side, and sentinel node on the right. I had a dreadful time with the AC part of chemo, being hospitalised after each dose, for a total of 56 days and nights altogether. The shortest stay was 8 days, and the longest was 17. The last dose was delayed by eight days, and reduced by 25%. I felt like throwing in the towel too, but I knew that I had one shot at this for a cure and so kept on plugging. The pathology from both removed breasts and all the nodes found a 100% pathological response to the chemo, with no live cancer cells found at all, only the (quote), empty tumour beds. That made it all worth while for me. I'm now five years post active treatment, aside form letrozole tablets as I' was hormone positive, and remain NED...no evidence of disease. Chemo is hard...not so hard for some...and very hard for some, but in my case, it was deadly for my cancer, and for that I'm glad. I strongly recommend you discuss this fully with your treating team, and see if maybe they can either reduce the dose or change your chemo. Unfortunately we only get one bite of the apple, and there's no rewind button. I wish you well with your ongoing treatment.