It will depend on which drugs you're going to have Linda. I had six months of AC and CMF in 2002 which made me feel sick for about 6 days then totally fine for 2 weeks each cycle. During those 2 weeks, I was able to work out at the gym, do canteen duty, work part time etc. This year I had 3 months of TC, and I worked from home with no problem, except for days 4 and 5 when my bones were achy. I had no nausea or vomitting with the TC, just tiredness and aches/pains. Having it on a Thursday would be a great idea. I found both times that the treatment was much more manageable than I had imagined it would be. In the two days before treatment, I would clean the house, change everyone's sheets, cook a few dinners, and then rest after treatment. Do you know what drugs you'll be having yet?