Hi, I'd be interested to hear from anyone who has switched from zoloft to another antidepressant due to zoloft apparently inhibiting the effectiveness of tamoxifen??...I've had mixed responses from my medical treatment team and read mixed responses from internet sites/drug interactor sites and media releases etc. Some research states without a doubt that zoloft shouldn't be taken while on tamoxifen, as it can interfere with the enzyme known as CYP2D6 that stimulates the activation of tamoxifen. BCNA website only refers to Aropax (paroxetine) as being a CYP2D6 inhibitor. Just wondering if anyone has switched from zoloft to a different anti-depressant because they are on tamoxifen...and if so which one, and how they are finding it? Celeste