I've found numbing the skin with ice works well, i've had 8 Zoladex injections and only one has been painful. Just curious, i've not been told how long I will be on Zoladex, is there a reason for the two year timeframe? I am almost 44 and asssumed I would be taking it for at least five years (menopause). I was very unlucky and despite chemo induced menopause, my periods returned just before starting hormone treatment, very unimpressed with that.