I agree with Deanne, bone density and vaginal atrophy are two issues I have also dealt with. My bone density before I started was terrific, and with some care it will see me through but it was originally way above what might be expected, "at my age" (a phrase I have learned to quietly loathe!) but has certainly been impacted on in three and half years. Vaginal dryness is also something that might have started "at my age", but I am certain it is Femara. You can ameliorate the problem and as far as I know it does not affect everyone. On the positive side I have had no aches, pains, arthritis-type symptoms, flushes or anything of that sort.