The information available on the Breast Cancer Network Australia website is not medical advice and is provided for information purposes only. It should not be viewed as a replacement for a consultation with a qualified medical professional. Our website is designed to offer information and support to the general public. Be aware that we do not provide any medical advice, and for medical advice we recommend you speak to a qualified medical professional or doctor. 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and a question re liver issues.","id":"message:129260","revisionNum":1,"repliesCount":10,"author":{"__ref":"User:user:3203"},"depth":0,"hasGivenKudo":false,"board":{"__ref":"Forum:board:general-treatment-and-surgery"},"conversation":{"__ref":"Conversation:conversation:129260"},"readOnly":false,"editFrozen":false,"moderationData":{"__ref":"ModerationData:moderation_data:129260"},"body@stripHtml({\"truncateLength\":200})":"New here, so first post 😊 I was diagnosed in November last year with HER2 + BC with lymph node involvement, and while not struggling so much with chemo so far, apart from last one in round 1 (but fo...","body@stringLength":"2684","rawBody":"New here, so first post 😊 I was diagnosed in November last year with HER2 + BC with lymph node involvement, and while not struggling so much with chemo so far, apart from last one in round 1 (but for other reasons), I’ve had a few ‘ curve balls’ thrown at me along the way. I had the first 4 two weekly rounds with the ‘red devil’ ( which I chose to call ‘angel’) but a large clot firmed near my portacath when it was placed (it’s also in the right chamber of my heart) so now on blood thinners and unsure what will happen come surgery in June if it hasn’t dissolved by itself! It is an unusual thing to happen, so go me! I’ve never had clots before, am a fairly fit 64 yr old and have never even had problems with swollen feet on planes. Go figure 🤷🏼♀️ Then, after my fourth go at round 1, I became incredibly tired, and basically slept for 4 days. I became so weak, that I passed out and ended up in a wheelchair for several days. My oncologist put me in hospital for hydration and blood transfusions where they discovered I had a major lung infection called PJP. I was in hospital for 2.5 weeks on IV antibiotics and was even oxygen dependent for about 4 days. A very sick girl! So I think the problem wasn’t as much the chemo, but the infection that was lurking for weeks - I’m guessing the chemo didn’t help, though.
The good news is that even though I missed four chemo sessions, my lump had reduced greatly from originally 37 mm to 27 mm (just after the fourth dose ) to now 18 mm. Depth and width also less, so I’m glad that nasty round did it’s work! Lymph node also smaller than last time.
The question is, has anyone experienced any liver enzyme level problems? I’ve just done round 2 of my 12 week regime with wk 1 being a mixture of Perjeta, Herceptin (Trastuzumab) and a Taxol. Blood test from the first one showed levels twice as high as they should be. The oncologist came and said ‘all fine to go ahead, as this level is ‘grade 1’ Grade 2 is apparently 5x and Grade3, 10x. If levels go up, they will reduce the meds.
My big concern is of course is that if this happened in wk 1, what on earth would it be like by wk 12? The first two drugs are only given every four weeks, but I believe I have them later as well after radiation therapy.
These are the drugs attacking the protein and making it less likely for return, so biggest worry is that I won’t be able to have them at all.
I’m just wondering if anyone has had a similar experience?
Sorry such a long post, but I’m tired of these ‘curve balls’ 😕
","kudosSumWeight":0,"postTime":"2024-03-08T14:50:15.000-08:00","images":{"__typename":"AssociatedImageConnection","edges":[],"totalCount":0,"pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null}},"attachments":{"__typename":"AttachmentConnection","pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null},"edges":[]},"tags":{"__typename":"TagConnection","pageInfo":{"__typename":"PageInfo","hasNextPage":false,"endCursor":null,"hasPreviousPage":false,"startCursor":null},"edges":[]},"timeToRead":2,"currentRevision":{"__ref":"Revision:revision:129260_1"},"latestVersion":null,"metrics":{"__typename":"MessageMetrics","views":191},"visibilityScope":"PUBLIC","canonicalUrl":null,"seoTitle":null,"seoDescription":null,"isEscalated":null,"placeholder":false,"originalMessageForPlaceholder":null,"messagePolicies":{"__typename":"MessagePolicies","canModerateSpamMessage":{"__typename":"PolicyResult","failureReason":{"__typename":"FailureReason","message":"error.lithium.policies.feature.moderation_spam.action.moderate_entity.allowed.accessDenied","key":"error.lithium.policies.feature.moderation_spam.action.moderate_entity.allowed.accessDenied","args":[]}}},"archivalData":null,"customFields":[],"body":"New here, so first post 😊 I was diagnosed in November last year with HER2 + BC with lymph node involvement, and while not struggling so much with chemo so far, apart from last one in round 1 (but for other reasons), I’ve had a few ‘ curve balls’ thrown at me along the way. I had the first 4 two weekly rounds with the ‘red devil’ ( which I chose to call ‘angel’) but a large clot firmed near my portacath when it was placed (it’s also in the right chamber of my heart) so now on blood thinners and unsure what will happen come surgery in June if it hasn’t dissolved by itself! It is an unusual thing to happen, so go me! I’ve never had clots before, am a fairly fit 64 yr old and have never even had problems with swollen feet on planes. Go figure 🤷🏼♀️ Then, after my fourth go at round 1, I became incredibly tired, and basically slept for 4 days. I became so weak, that I passed out and ended up in a wheelchair for several days. My oncologist put me in hospital for hydration and blood transfusions where they discovered I had a major lung infection called PJP. I was in hospital for 2.5 weeks on IV antibiotics and was even oxygen dependent for about 4 days. A very sick girl! So I think the problem wasn’t as much the chemo, but the infection that was lurking for weeks - I’m guessing the chemo didn’t help, though.
The good news is that even though I missed four chemo sessions, my lump had reduced greatly from originally 37 mm to 27 mm (just after the fourth dose ) to now 18 mm. Depth and width also less, so I’m glad that nasty round did it’s work! Lymph node also smaller than last time.
The question is, has anyone experienced any liver enzyme level problems? I’ve just done round 2 of my 12 week regime with wk 1 being a mixture of Perjeta, Herceptin (Trastuzumab) and a Taxol. Blood test from the first one showed levels twice as high as they should be. The oncologist came and said ‘all fine to go ahead, as this level is ‘grade 1’ Grade 2 is apparently 5x and Grade3, 10x. If levels go up, they will reduce the meds.
My big concern is of course is that if this happened in wk 1, what on earth would it be like by wk 12? The first two drugs are only given every four weeks, but I believe I have them later as well after radiation therapy.
These are the drugs attacking the protein and making it less likely for return, so biggest worry is that I won’t be able to have them at all.
I’m just wondering if anyone has had a similar experience?
Sorry such a long post, but I’m tired of these ‘curve balls’ 😕
"},"Conversation:conversation:129260":{"__typename":"Conversation","id":"conversation:129260","solved":false,"topic":{"__ref":"ForumTopicMessage:message:129260"},"lastPostingActivityTime":"2024-03-13T15:05:57.000-07:00","lastPostTime":"2024-03-13T15:05:57.000-07:00","unreadReplyCount":10,"isSubscribed":false},"ModerationData:moderation_data:129260":{"__typename":"ModerationData","id":"moderation_data:129260","status":"APPROVED","rejectReason":null,"isReportedAbuse":false,"rejectUser":null,"rejectTime":null,"rejectActorType":null},"Revision:revision:129260_1":{"__typename":"Revision","id":"revision:129260_1","lastEditTime":"2024-03-08T14:50:15.000-08:00"},"ForumReplyMessage:message:129266":{"__typename":"ForumReplyMessage","id":"message:129266","conversation":{"__ref":"Conversation:conversation:129260"},"author":{"__ref":"User:user:1914"},"revisionNum":1,"uid":129266,"depth":1,"hasGivenKudo":false,"subscribed":false,"board":{"__ref":"Forum:board:general-treatment-and-surgery"},"subject":"Re: Newbie and a question re liver issues.","readOnly":false,"editFrozen":false,"moderationData":{"__ref":"ModerationData:moderation_data:129266"},"parent":{"__ref":"ForumTopicMessage:message:129260"},"body":"@kymbo I'm so sorry you've been through so much, I can't really give much advice as I didn't have to have the chemo, but my liver function tests di show my liver enzymes were up high, but I think they were caused from some herbal supplements I was taking, just wondering do you take any supplements at all? Good luck with it all, you sound like one tough cookie :) Cindi x","body@stringLength":"383","rawBody":"@kymbo I'm so sorry you've been through so much, I can't really give much advice as I didn't have to have the chemo, but my liver function tests di show my liver enzymes were up high, but I think they were caused from some herbal supplements I was taking, just wondering do you take any supplements at all? Good luck with it all, you sound like one tough cookie :) Cindi 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