Good news about your bone density, always good to start with money in the bank as it were with letrozole! I take Femara in the morning, I have never had any joint pain or flushes or weight gain for that matter. It has had some effect on my bone density and I am hoping five years (May this year) will be it. But no need so far for any preventative treatment, my bone density was very good for my age when I started. I have also a considerable degree of vaginal dryness. May have occurred anyway but I think Femara has increased it. Good luck!