@KimF hi. I have been on letrozole since December 2021, I got hot flushes pretty quickly, bone aches started about 1-2 months ago, just had a recent scan but don't know results from bone scan yet, bone density ok so far. I don't have vagina dryness but do have vagina tightness (like I am a virgin again and painful during intercourse) this is another symptom of letrozole, can be treated as well. I am on another drug as I have stage 4 metastatic breast cancer to the liver so get symptoms from them as well