I was on Letrazole for 6 years. I had all those same side effects too, but with time the side effects all nearly disappeared. It took a few years, but fish oil helped. Unfortunately I am now almost osteoporotic, so I have been taken off the Letrazole and put back on Tamoxifen. I feel that my hot flushes have changed again, but my joints are great. I have been badly affected by hot flushes, since well before Breast Cancer. I am into my 11 year of hot flushes, but they are not as intense as they were before BC.