We had a trip booked to Cairns plus I also had major dental beforehand and I did not want to start AI until after so waited 6 weeks. I was not on any hormones until we got back. Had the impression from medical oncologist that takes about 3 months before bone thinning problems occur - this may also apply to other major side effects not sure - worth discussing with your doctor though. I have been on AI for 7 plus weeks and not too bad this far - bit of joint pain which corrects when I get moving but admittedly noticeably more tired.