Hi again primek - just read in the presentation that majority of people followed on Hera trial were node positive, tumours >2cms and equal splits with er and or pr positive. They also quoted age but only remember upper level at <58 or perhaps 59. I'll do more research before posting links again. I would never want to spread doom and gloom, I thought it was good that research is ongoing to help when herceptin does not work on its own.