Reading others comments @caccal made me remember more clearly what happened with me and how it might answer your question. I was originally diagnosed with 2.5cm ILC no node involvement. I was supposed to have a partial followed by radiotherapy. When the path report came back, it was 4.5cm requiring a mastectomy and had spread to 3 nodes. This changed my treatment plan to include AC-T as well. I won't lie and say it was easy, but with the right medication, I got through it. I think the hardest part through most of it was the extreme fatigue.