Oh @socoda, you made me laugh, yes I'm sure less than cordial! Some people just don't think. @Zoffiel, I'm so glad the claratine has made a difference for you! Did you have the targine last time? I think I definitely need to get something better organised for my next dosetaxol as the last one was so painful even with the claratine. Targine is a slow release endone with naloxone so it doesn't have the same effects on the gut like constipation and nausea, that plain endone has. I hope you're tolerating it well. Yes, I totally get you wanting to abandoned the whole process! I'm feeling that too but I just need to soldier on and get through it, hopefully we can counteract the side effect better this time.