It’s very variable! I was OK on A/C, lost my appetite for a day or so each cycle then back to normal - except for wine. Could not stand the taste! Sad but not a bad outcome in the scheme of things. Taxol (paclitaxel) took away my taste buds - coffee was alright (hooray!), wine was still awful, but almost everything else had simply no taste. Spicy food was recommended but made no difference. The things I could taste and enjoy were eggs, salad (lettuce, tomato, cucumber), avocado and banana! Boring and frustrating but not impossible. I had no nausea so nothing upset my stomach. Taste buds came back (intact!) soon after I finished chemo, hooray. Best wishes with it all.