Hi Karen:):) I feel like I am an expert on Tamoxifen lol!!! I have been on it for 2 years now.In the beginning,it definitely gave me terrible hot flushes.Sleep was terrible,and I had leg cramps.Two years on,everything has settled.If you asked me when did it change,I couldn't tell you,but I can tell you it does get better.My oncologist told me it would,and she is always right!!! I took it at night to start,then in the morning.It makes no difference !! I now take it in the morning,along with 2 Blackmores magmin tablets,which stop my leg cramps.I feel really healthy now,and I feel that taking a tablet is a small thing to do for reassurance about our BC coming back:):) Cheers Robyn xox