Hi there @Sylva...I'm so sorry you've had to join our club and than you are feeling so overwhelmed. I hope I don't come across as someone who's trying to beat you in the "Who's got it worse" competition, but I too have a number of health issues, some very similar to yours. My intention is to reassure you that even us "old crocks' (me, not you), can keep on keeping on. I also had terrible osteoporosis even before diagnosis. Not as bad as yours, to be sure, but I have had two spontaneous rib fractures without apparent injury. I also have three autoimmune diseases...all connective tissue diseases which cause major issues. You mention that you have psoriatic arthritis, which, as you know, is an autoimmune disease. I'm on more tablets than I can count for these as well as letrozole, which you'll be starting. I have a wheeled walking frame, so not a wheelchair yet, but my one other condition has me with interstitial lung disease, which is progressing, and will probably leave me in one too. I have a prolia injection every six months for my bones, and all my readings on the osteoporosis charts have improved. I have no problems with the prolia, other than a headache the day following the injection. I've been on the letrozole since mid 2017 and none of my joint, muscle, tendon or skin issues are any worse than I would have expected over four years. I had both boobs off in 2017, with node clearance on the left side and sentinel node on the right. I found the surgery to be less painful than when I had my appendix our when I was sixteen...those days a good six inch cut. It's by no means easy, but as arpie often says, this disease messes with your head more than anything else. The advice given so far by the other members is gold, and I hope my five cents worth will set your mind at ease as far as dealing with this on top of life altering other medical conditions. It's not as easy as for those entering the shitfest with strong and healthy bodies (other than the cancer of course). You're not alone, and we'll all be here to cheer you on from the sidelines, and to be a listening ear when you need one too. Big hug...Ally.