@KayB55 As @primek has said, whether chemo first is advisable depends on the type of cancer and the stage. Your oncologist is the best one to advise about how useful it is. My surgeon ordered chemo first; that was a shock, because the diagnosing doctor at the breast clinic had said I should have a mastectomy straight away. But a week later the oncologist then said there was no strong medical benefit in doing chemo first. She said because mine was Invasive Lobular Carcinoma and was very large (they thought it was about 8-9 cm but it turned out to be 12 cm): basically a huge spiderweb of tiny subtle cells that are very difficult to detect. She explained it to me as: lumps shrink better in response to chemo because the chemo hits the target more easily. In the face of that information, I chose to have surgery first. I was also influenced by my gut feeling: I didn't want to go into surgery weakened by chemo physically and psychologically. But that was me. Everyone is different. You just need to gather as much information as possible and follow your gut instinct. All the best. <3