ccasper
9 years agoMember
Exercise on chemo
Hi Ladies I just wanted to post on here to see people's responses. I have had a delay due to low neutrophils but they are back up and having chemo as we speak. I was talking to a nurse and a so...
Regular exercise is a practical way to improve immunity. However, the exercise effects on immunity are highly dependent on exercise intensity, duration, and frequency. Acute severe exercise (ASE), marathon running in particular, increases tissue damage and stimulates the secretion of many proinflammatory cytokines (e.g., tumor necrosis factor > and interleukin (Iβ) 1A)[8,20] and an antiinflammatory cytokine (IL-6).[22] ASE also increases the risk of upper respiratory tract infection.[14,32]In contrast, chronic moderate exercise (CME) lowers many proinflammatory cytokines (e.g., C-reactive protein and IL-1) and elevates an anti-inflammatory cytokine (IL-10) in the circulation.[22] As a whole, CME improves immunity as indicated by lowered susceptibility to viral and bacterial infections.[14,32]
Because ASE and CME have diverse effects on immune responses, they may differentially regulate neutrophils. Neutrophils, the major cell type responsible for innate immunity, are short-lived leukocytes that undergo spontaneous apoptosis. Our recent studies have shown that ASE accelerates neutrophil apoptosis, whereas CME delays it.[24,25] Whether ASE and CME also exert differential effects on neutrophil functions deserves further investigation. When infection occurs, neutrophils rapidly migrate to the infection site (chemotaxis) and ingest the pathogens (phagocytosis). Whereas some studies demonstrate that ASE paradigms enhance neutrophil chemotaxis and phagocytosis,[5,7,17] other studies show either suppressive effects or no effect at all.[6,23,31] These controversies might be due to the different physical fitness levels of subjects, different exercise protocols, and different assay methods used in various studies. So far, relatively few studies address the effects of CME on neutrophil functions, and self-controlled studies are still lacking.