I did this some time ago now, but had A/C followed by Taxol and herceptin and then hormonal therapy (had a mastectomy, no radiation). I continued working throughout (office and other locations, I do events). Had no fatigue or nausea which was a big plus, irritating side effects with Taxol including neuropathy but not enough to stop working. Work was good for me, it was a distraction and I had a supportive boss and staff. The general view is that Taxol is easier than A/C but I found A/C relatively easy. Everything except the neuropathy with Taxol sorted itself out once treatment stopped. Good luck!