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Mareealso's avatar
Mareealso
Member
3 months ago

Exemstane and Nausea

Hi Everyone, Just wanting to know if anyone else has had severe nausea with Exemstane and if so, did it get better over time? I had my diagnosis, op and chemo 2023-2024 and was then placed on Arimidex. I then developed nausea and liver function tests showed higher levels, indicating that my liver was struggling. I was then taken off Arimidex and placed on Exemstane (2025) and after several months, am now having persistent nausea. Blood and Liver Function tests are normal however I am struggling with the “gastric” sides of things. I have just recently had to have  an iv of anti nausea medication in hospital plus an acid-reflux iv. I have been given tablets but was told that these are only for short term use. Any ideas?

treatment

1 Reply

  • arpie's avatar
    arpie
    Member
    3 months ago

    I am so sorry you are having this side effect - strange that you had it with Arimidex as well as Exemestane! .... Nausea 'is' one of the side effects but I was lucky & didn't have it.  I was only on Arimidex for 6 months before swapping to Exemestane & was on that for over 6 years with no nausea, just the usual aches & pains.

    When do you take the tablets?  I used to take mine at night.  Can you change it to a different time & see if it gets better? 

    Do you take them before or after a meal?  Maybe Swap it around.

    Are you taking the 'actual' tablets, or one of the Pharmacy 'copies'?  Some of the copies use a different coating on the tablet - which might affect you adversely.

    Are you on anti-inflammatories at all?  I had a major liver function fail when I was put onto Mobic for a hip injury! My liver almost failed! 

    Have you had an 'uppie & downie' (colonoscopy/gastroscopy) in recent years (or ever had them??)  If this nausea persists, I think it would be wise to ask to have them done, to make sure there are no issues down there. 

    Acid reflux is often a problem associated with gut issues - and the tablets you are on only 'mask' the issue, it won't fix it.   :( 

    I've put a brick under both top legs of my bed, putting it on a very slight 'angle' (not enough to interrupt your sleeping) but enough to stop the stomach acid from going up into your throat!   I have regular uppies & downies too very 5 years.

    Take care & all the best xx