@kmakm yes this is my experience on Arimidex and Aromasin, it hasnt changed in 2.5yrs, exercising doesnt change it at all, makes me feel better mentally that's all. Having said that Im not taking osteo panadol everyday either, and I'm working 5 days a week....feeling I am struggling though with it to be honest. I really do have wondered though and I asked my Oncologist if it is the combination of chemo and then the meds, he said unfortunately yes. This is why his report to the Income Protection said I would never be rehabilitated enough for full time work as long as I am on meds. I have to work, I also want to as well for my sanity I suppose. It doesnt go away completely you are right but the osteo takes the edge off, Im on my feet all day so even strengthening my legs riding my bike doesnt help the ankle/feet pain I live with. What can you do? he said you can come off it anytime you like, up to me and that's the alternative. I have a very different mindset I think having already had a recurrence after doing 'all the right things' I CANNOT imagine how someone who also has done so, is now facing metastatic breast cancer. x