My advice is always to contact the clinic with anything concerning. I had shocking nausea and reflux starting 24 hours after my first chemo and the meds they had given me made no difference. I didn't realise that I could bug them on the weekend and so spent some extremely miserable days where I couldn't lay down and I couldn't sit up for more than a few minutes. Rang the clinic on the Monday and had a script faxed to the local chemist for better meds and it all changed. So, ring up straight away to tell them about the nausea and the chest tightness.