Hullo @red1 I am not in your position, thanks be, with young children and still so young yourself, but I believe at any age you need to listen to your body. Your cells are talking to you. Chemo is a very blunt instrument as @Sister says and cancer is a strange and cunning adversary. Not to be depressing but in some cases it recurs no matter what chemo and other treatments someone has. It's a gamble, and those statistics have well-known limitations being mostly based on five year survival rates. It's also very important what your oestrogen receptor status is. If you are positive then you will go on hormone blockers of some kind which will be an added survival factor. If not maybe the fourth dose might be worth it. But quality of life has to be considered. So many of us here are struggling with that, chemo or no chemo. Best wishes and a warm hug.