Hi there @Red1....Aaah the old stats dilemma. One percent is one percent, depends how you look at it. A 1% discount off purchases at a shop, is deemed insignificant. However, 1 % of pupils in average school of 1000 pupils is 10. If a crazy person ran around with a gun and shot ten pupils, the public (and the parents, family and friends) of the ten children would think that same one percent to be high. The question I would ask myself is this. If the cancer did in fact return, would I regret not having had that final dose? Even taking into consideration the potential further risks? My reasoning to myself was that I'd rather go into my box later with poppers or press studs on my clothes, than sooner with buttons. (One of their benchmarks for grading peripheral neuropathy in the hands is, can you do and undo buttons)?