As @Blossom1961 says, reactions vary. I was fine on A/C apart from hair loss, no
nausea, no fatigue. I did get a mild heart arrhythmia after I finished A/C but it may have been caused by a number of things. With paclitaxel I got an occasionally bloody nose, lost my tastebuds for a while but did get peripheral neuropathy which can linger. Nowadays you can get ice treatment for hands and feet to try and avoid this which I think is worth doing. The tingling/numb/painful aspects of PN usually abate after treatment but not always. Still no nausea or fatigue. All symptoms either cleared up after treatment ended or have proved manageable, but avoid the PN if you can. Best wishes.