It's hard to predict @taboogal - everyone reacts a bit differently. I've suffered from nausea, indigestion and reflux, and sever fatigue throughout chemo, both on AC and taxol. AC has become a bit of a distant memory but as long as I kept the drugs up, I wasn't too bad (the first one when I didn't have strong meds for the early days was a living nightmare). I ended up with Ativan for nausea (and Somac for the indigestion and reflux (which has now been changed to Nexium). The Ativan is an anti-anxiety drug but also works for nausea and to be perfectly honest, the anti-anxiety bit has not been a problem! The drawback is that you can't take it if you have to drive or anything like that. I found that with AC, Day 1 wasn't too bad but the downward descent would happen during Day 2. Days 3 & 4 were best spent sleeping and I would probably lose most of the day. By Day 5, I was usually able to manage short walks and Day 7, I was pretty much as good as I would get - most of my energy in the morning but crashing and burning during the day - and terrible if I overdid it. I was managing 5km walks each morning in my good weeks, up until the last AC when shortness of breath became a factor.