Hi Etta, I have never had any reaction to Zometa - now on it 3 monthly. As with Xgeva, there is a small risk of osteonecrosis of the jaw, which can be nasty. I am extremely careful about oral health. Best wishes.... Pam
hi Etta, I am a fan of Zometa , it has helped control the pain from bone mets , reduced the calcium in my blood ,and I won't be a bigger risk of fracture. It can be difficult the first few infusions , but rest and plenty of fluids help. I have been on it 21 months now and no problems