I was on Xeloda too and hand and foot syndrome was severe on my feet. They split open pretty badly and I had difficulty walking. I used lots of different creams and most provided some relief but not healing. One of the things I found most helpful to put on the splits was the clear very thin dressing that is used to cover the canula when you are having chemo. Think it might be called Opsite (not sure), its available in pharmacies for about $2 a piece. It worked by holding the skin together so that it didn't split more when walking. Not a cure but very helpful. Have just come off it as my TMs started to trend, ever so slowly, upwards.