Hi Karen I'm the same as your Mum and, 6 years down the track, I've had about 7 different chemos. I'm not sure what options the Onc is talking about once the chemos stop working. Late last year my lovely Onc told me that the research all shows that taking more chemo would not have any benefit for me and, as the current chemo had stopped working, she suggested that I stop having chemo altogether. Unusually for my Onc, it was all a bit sudden, and she did offer a tablet form which I could take at home as I live an hour from all Onc services. So I now take a tablet of cyclophosphamide every day and then 2 tablets of methotrexate on Mondays and Tuesdays - which is still chemo. My Onc did tell me about research being run at Newcastle Private Hosp (NSW) and if I had one of a few proteins then they could be given trial treatment for that, however I turned out not to have any of those proteins. Apart from that, I haven't been told about any other options. Hope this helps!