Hi Judy, I've been on a clinical trial for most of this year - with trial medication/placebo, Letrozole / Zoladex / Xgeva. I swapped jobs - from 3/4 days part time (newish job and workload was 5 days worth) to returning to a retail job for 2 half days. I find that I have some memory fog and am very tired on my work days. If you have a supportive work environment, I would just move down one day at a time... give your body a chance to see how it feels about the drugs. I rushed to swap jobs after my diagnosis went from nothing to mbc in a few weeks. If you have a workplace that are willing to give you time to see what will work for you... go for it!! The emotional support alone will be worth holding on to! All the best. Amanda